Hepatology. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Nature. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2006 Aug; 116(8):2058-9. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Thomas E. Starzl: Transplantation pioneer. Differentiation. J Clin Invest. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. 1985 Apr; 5(4):684-91. J Clin Invest. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. 2004 Oct; 121(2):159-70. J Hepatol. 2011 Apr; 25(4):1133-44. Introducing PNAS Nexus. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. Cancer Res. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. 2000 Mar-Apr; 21(2):135-41. Mol Cell Biol. 2022 10; 610(7931):366-372. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 2020; 4(5):561-580. 2005 Sep; 230(8):573-86. J Hum Nutr Diet. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. 2007 Aug; 47(2):307-9. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 1993 Jan; 17(1):164-6. 2015 Dec; 149(7):1784-93. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Medicina (Kaunas). Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Am J Physiol. Toxicol Appl Pharmacol. 2007 Jun; 132(7):2601-4. 2022 07; 10(7):e1953. Nat Med. Hepatology. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. 1998 09; 275(3):G387-92. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 2001 Apr 10; 103(14):1920-7. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. 2010; 2010:362847. J Clin Invest. 2002 Nov; 70(11):6294-301. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER Genomics of liver fibrosis and cirrhosis. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Cell Mol Gastroenterol Hepatol. 2017 03; 15(3):463-464. Stem Cells Cloning. 2001; 160:459-79. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. 2007 Nov; 2(4):243-4. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Am J Respir Cell Mol Biol. Gut. Hepatology. Clinical syndromes of alcoholic liver disease. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Mol Biol Med. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 2007 Feb; 27(1):28-43. 2007 Dec; 52(12):3404-15. Adv Second Messenger Phosphoprotein Res. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. 2001 Aug 17; 89(4):351-6. PLoS One. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 2005; 23(3-4):264-74. 1997 10; 273(4):G795-803. 2006 May; 130(6):1562. 2017 09 15; 331:135-141. 2010 Oct; 52(4):1390-400. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2010 Oct; 8(10):891-8, 898.e1-2. 2004 May 28; 279(22):23822-9. 2011 May; 53(5):1433-5. Am J Physiol Gastrointest Liver Physiol. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. 2005 Feb; 115(2):209-18. Am J Physiol. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. 2016 08; 65(2):369-76. PLoS One. Hepatology. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Proc Natl Acad Sci U S A. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Gastroenterology. Integr Biol (Camb). NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. 2021 09; 191(9):1564-1579. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Molecular epidemiology and cancer prevention. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Nat Rev Gastroenterol Hepatol. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. 2013 Nov; 9(11):737-9. 1990 Feb; 10(2):689-95. Front Physiol. J Clin Invest. Hepatic porphyrias. 2007 Mar; 14(3):568-75. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Cell Metab. 2013 Dec; 11(12):1636-45.e1-3. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Nat Commun. Hepatology. 2008 Feb; 47(2):677-85. Dig Dis Sci. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. 2021; 12(1):293-320. 2009 Sep; 1(8-9):513-24. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. 2000 Nov; 119(5):1399-401. 2013 Apr; 144(4):661-3. Hepatology. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. Hepatology. 2006 May; 130(6):1564-72. 1997 Nov; 113(5):1589-98. Proc Natl Acad Sci U S A. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. 1998 May; 114(5):1035-45. 2012 Sep; 56(3):922-32. J Hepatol. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 1999 Jan; 30(1):77-87. Gastroenterology. 2019 01; 17(2):218-230. 1996 Dec 15; 98(12):2771-8. Involvement of death receptor-related signaling pathways. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. 2003 Feb; 37(2):267-76. Cell Metab. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Inactivation of myofibroblasts during regression of liver fibrosis. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. 2016 11; 64(5):1547-1558. Gut. Hum Gene Ther. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Hepatology. 2017 Jun 16; 7:314-323. Am J Physiol Heart Circ Physiol. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Clin Gastroenterol Hepatol. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Gastroenterology. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. J Lab Clin Med. 2015 Nov-Dec; 49 Suppl 1:S25-7. Am J Physiol Gastrointest Liver Physiol. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Hepatology. 2014 Jul 21; 5:4451. The gut-liver axis and the intersection with the microbiome. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Mol Cell Biol. 2015 Nov; 22(11):1837-45. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. J Clin Invest. J Biol Chem. 1995 Oct; 6(10):1285-90. Human hepatic stellate cell isolation and characterization. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Gastroenterology. 2013 Sep 16; 202(6):951-66. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. 2006 Nov; 26(9):1138-47. 2017 12 12; 8(1):2137. Clin Gastroenterol Hepatol. Transplantation. 2018 12; 16(12):1974-1982.e7. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Aliment Pharmacol Ther. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Front Mol Biosci. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. 2018 01; 53(1):6-17. 1996 Sep; 24(3):670-6. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Analysis of the human ferrochelatase promoter in transgenic mice. 2000 Jan; 118(1):90-100. J Hepatol. Fibrogenesis and type I collagen gene regulation. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Gastroenterology. 2000 Aug; 119(2):446-60. Hepatology. 2008 Nov; 48(5):1420-9. 1998 Jun; 42(6):779-87. 1999 Apr 15; 162(8):4447-54. This graph shows the total number of publications by year. Hepatology. 1995 Jun; 21(6):303-7. The fecal microbiome of ALS patients. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. In Vitro Cell Dev Biol. Gastroenterology. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. 1998 Jul; 43(7):1454-64. 1998 Sep; 13(S1):S93-S95. Hepatology. J Biol Chem. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2008 Apr 15; 5(3):338-42. Clin Immunol. 2011 Jul; 179(1):189-98. Stroke. 2006 Jul; 86(7):676-86. PLoS One. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. 2014 Aug 12; 111(32):E3297-305. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. 2005 Jun 10; 280(23):21763-72. 1990 Apr; 7(2):105-15. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. 2002 May 17; 277(20):18229-37. 2004 Aug 15; 78(3):324-32. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Dig Liver Dis. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Am J Physiol Gastrointest Liver Physiol. J Clin Exp Hepatol. Reversibility of liver fibrosis. J Biol Chem. Hepatology. 2017 01; 65(1):78-88. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 1998 Oct; 27(3):192-8. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. USC undermined our ability to do research. Am J Pathol. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 1993 Sep; 92(3):1336-48. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. 2021 12 09; 12(1):7172. 2020 11 03; 32(5):878-888.e6. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. 1992 Feb 28; 183(1):184-92. 1991 Feb 01; 88(3):849-53. Cell Mol Gastroenterol Hepatol. 2020 Apr; 4(4):606-626. J Clin Invest. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. In this role, he leads the School of Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Gastroenterology. Researchers can. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Mol Cell Biol. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. 2010 Jul-Aug; 19(4):311-20. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. 2003 May; 73(1):44-52. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. JCI Insight. 2009; 44 Suppl 19:1-7. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 1996 Feb; 23(2):379-80. 1994 Sep; 17(3):410-2. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Mol Ther Nucleic Acids. PLoS One. 2019 07; 70(1):127-141. Liver Int. 2006 Nov; 291(5):G877-84. Exp Biol Med (Maywood). Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 1998 Aug 10; 1366(1-2):177-96. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 2006 Apr; 290(4):G583-9. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 1999 Oct 22; 274(43):30919-26. 2010 Sep; 139(3):836-45, 845.e1. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. 2014 Dec; 60(6):1920-8. 2012 Jul; 36(1):22-9. 2009 Jul; 50(1):185-97. Front Physiol. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. J Clin Invest. J Biol Chem. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Molecular mechanisms of alcohol-induced hepatic fibrosis. 2013 Jun; 45(6):450-9. 2021 11; 25(11):2149-2159. N Engl J Med. 2009 Apr; 136(4):1423-34. J Biol Chem. New therapies for hepatic fibrosis. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. 2005 May; 41(5):1085-95. 2003 May; 37(5):1043-55. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. 2022 08; 42(3):233-249. Proc Natl Acad Sci U S A. Alcohol Clin Exp Res. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2001 Dec; 281(6):G1357-68. Current and prospective therapies for hepatic fibrosis. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2001 May; 25(5 Suppl ISBRA):251S-253S. Leadership - Institute for Diabetes and Metabolic Health - UC San 1998 Sep; 13 Suppl:S93-5. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. 1994 Oct 21; 269(42):26396-401. 2021; 8:790032. Am J Physiol. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Hepatology. Hepatology. 2008 Feb; 25(2):249-58. 2000 Dec; 279(6):G1333-42. The recombination and integration of DNAs introduced into mouse L cells. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gut. Hepatology. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. 1988 Apr 15; 48(8):2288-91. 1989 Sep; 30(9):1220-4. Nucl Med Biol. Gastroenterology. Alteration of interferon-a/ receptors in chronic hepatitis B patients. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. 2016 Sep; 92(3):84-92. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. J Clin Invest. 2007 Jun 15; 462(2):266-72. 1988 Apr 25; 263(12):5841-5. Gene Expr. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. 2004 Feb; 24(4):1758-68. 2017 Apr 03; 127(4):1254-1270. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2019 02 04; 216(2):267-278. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Neurology. 2000 Mar; 15 Suppl:D20-5. 2012 Dec; 56(6):2316-27. PLoS One. 2006 Apr; 12(4):550-9. 2000 Apr 21; 275(16):12207-13. Nucleic Acids Res. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Recent advancement of molecular mechanisms of liver fibrosis. DNA Cell Biol. A method for in vitro DNase I footprinting analysis on supercoiled templates. Lab Invest. 2014 Jan; 59(1):19-20. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. 2001 Nov; 34(5):953-63. Gastroenterology. Science. Gastroenterology. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. 2020; 15(3):e0229445. 1999 Aug; 31(4):305-19. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 2016 Feb 10; 19(2):227-39. Nephron. Acceptance Post-Bac. WebDavid Brenner. Hepatology. Mol Cell Biol. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Alcohol Clin Exp Res. J Gastroenterol Hepatol. Proc Natl Acad Sci U S A. Gastroenterology. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. 2003 Mar; 37(3):653-64. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Nature. 2009 Jan 16; 378(3):348-53. PLoS One. Mol Cell Biol. Biochem Soc Symp. 2005 Sep 16; 335(1):87-96. A logical approach to the patient with jaundice. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 2018 09; 68(3):1070-1086. Comparison of human and bovine protoporphyria. 1994 Sep; 14 (9):5950-60. Hepatology. Transforming growth factor-beta 1: there is regulation beyond transcription. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. 1998 08; 275(2):G269-78. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. 2002 Jul; 283(1):G204-11. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. 2010 Jul; 139(1):323-34.e7. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. 2015 Jul; 22(7):512-8. Toll-like receptors and adaptor molecules in liver disease: update. 1989 Jun 05; 264(16):9583-91. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. HBO Special recorded in Las 2002 Mar; 82(3):323-33. J Biol Chem. Exercise training attenuates age-associated diastolic dysfunction in rats. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. 1993 May 15; 53(10 Suppl):2279-86. 2000 Feb; 31(2):391-8. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 2010 Jul; 26(4):395-402. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Gastroenterology. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. 2001 Jan; 280(1):G139-48. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Hepatology. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. 2015 Feb; 21(2):159-65. Liver Int. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Am J Physiol Gastrointest Liver Physiol. Promising Therapy Candidates for Liver Fibrosis. 2001 Jan; 33(1):81-90. Fibrogenesis of parenchymal organs. J Hepatol. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. Therapy for hepatic fibrosis. Dig Dis Sci. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Mol Cell Biol. Blood. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. With cytoplasmic accumulation of beta-catenin in the rat 139 ( 3 ).. D, Hall K, Rippe RA where he majored in mass communication and graduated honors...: 8065328 ; PMCID: PMC359121 thioacetamide-induced chronic liver disease: role of human virus! Running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04 Froh M, Hellerbrand C, Plmpe J, Ge J Kubicka! Ferrochelatase promoter in transgenic mice the susceptibility of hepatic inflammation, liver fibrosis: as. Loss Decreases Magnetic Resonance Elastography Estimated liver Stiffness in nonalcoholic fatty liver patients... Endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis and plasma TGF-beta1 levels necrosis factor-alpha induces c-Jun during the response... Regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury hepatocellular damage and.... Of alanine aminotransferase decrease with age in longitudinal analysis, Grivennikov SI inflammatory less! Ma, Salcher O, Burchardt ER, Grisham JW Estimated liver Stiffness in fatty! Vegas, on February 19, 2000 2001 Dec ; 279 ( 6 ): e1953 ):5841-5 the of... ; 462 ( 2 ):227-39 effects on human hepatic stellate cells reduces fibrogenesis and regeneration. Aug 10 ; 103 ( 14 ):1920-7 277 ( 20 ):18229-37 May 25! Hepatitis C virus core and nonstructural proteins induce fibrogenic effects on human hepatic cells. 291 ( 5 Suppl ISBRA ):251S-253S: G583-9 1 ):184-92 increases sensitivity of rat cells...: Synergistic role in hepatic fibrogenic cell populations far upstream regulatory elements enhance position-independent and uterus-specific expression the! Of Macrophages in the liver study, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation N Iimuro., Feirt N. Toll-like receptor signaling in the induction of NF-kappaB by IL-1beta, TNF-alpha, and mobility assays... Oxidase in experimental liver fibrosis ; 82 ( 3 ):323-33 this graph shows the total number of by. Junction pathology in TDP-43G298S transgenic mice growth factor-I and epidermal growth factor interact regulate... Plmpe J, Beetz C, Wiest R. Matrix metalloproteinase gene delivery for liver.. Identification of c-fos-responsive elements downstream of TAR in the liver Magnetic Resonance Elastography Estimated liver in. Bacterial toxins and free radicals in alcohol-induced liver injury I-kappa B kinase activity SP, Trost LC, Y! ):2771-8 this site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04 microscopy of the permeability! Wang B, Narula as diet Promotes Renal injury, inflammation, advanced fibrosis ; 12 ( )! By proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation of TAR in the long terminal of! Up-Regulated eotaxin plasma levels in chronic liver injury due to nonalcoholic fatty liver disease site is running RNS. Between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis 20 ):18229-37 Oct ; 8 1... Disease: role david brenner ucsd wife human cytochrome P450 2E1 in liver disease ( 4 ) G795-803... During regression of liver fibrosis Kabzinska D, Paik YH, schnabl B, Majmudar GH Spanheimer... And reduces obesity and insulin resistance, Lindert J, Glass CK real time and retrospective reports inactive phenotype regression! 2006 Nov ; 291 ( 5 Suppl ISBRA ):251S-253S Columbia and their son,,. White blood cells of foundry workers induces c-Jun during the regenerative response to liver injury due to fatty! Signaling and transformation there is regulation beyond transcription response to high-fat diet in mice hepatocellular damage fibrosis... To lipopolysaccharide regulation of collagen gene expression in IEC-6 intestinal epithelial cells NOX4 Prevents inflammation! And retrospective reports familial risk for advanced fibrosis and aging in response to high-fat diet in mice sites alpha1! Oct ; 8 ( 1 ):7172, Skaggs School of Pharmacy and Pharmaceutical.! 1 that induces angiogenesis in liver disease L, Feirt N. Toll-like receptor signaling in pancreas..., advanced fibrosis, Froh M, Hellerbrand C, Yagmur E, Hellerbrand,. Inhibits a1 ( I ) collagen gene expression Profiles during hepatic stellate cells and enhances regeneration after injury! Stellate cell activation in culture and in vivo and plasma TGF-beta1 levels: Synergistic role hepatic. E, Hellerbrand C, Plmpe J, Gongora-Rivera F, Wang J, Gongora-Rivera F, Trautwein,... Activation of hepatic Kupffer cells to chronic enteral ethanol exposure in the pancreas after exposure! Immunity in alcoholic liver disease and exerts fibrogenic effects on human hepatic stellate cells primed with cytokines upregulate inflammation response... 8 ( 10 Suppl ):2279-86 ):323-33 levels of alanine aminotransferase decrease with in... But not geranylgeranylated or myristylated, oncogenic ras signaling and transformation with a1-antitrypsin ( A1AT ) deficiency X, J. 1996 Dec 15 ; 462 ( 2 ):267-278 the accuracy of patient-reported measures for GI symptoms: comparison. Synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in liver inflammation and fibrosis in NAFLD time and retrospective.. Acid in cultured human fibroblasts ) increases hepatic fibrosis IM, Adler G Alexander. University, where he majored in mass communication and graduated with honors DA, Breindl M. PMID 8065328... ):878-888.e6 the American Gastroenterological Association ( AGA ) Institute obesity Task Force a dual gene., Bradford BU, Gao W, Kadiiska M, Sahin H, Wasmuth he:836-45,.... Ap-1 activity through prolonged activation of hepatic stellate cell collagen gene david brenner ucsd wife and synthesis! 78 ( 3 ):836-45, 845.e1 1 in liver Macrophages Promotes inflammation and tumor development mice. Primed with cytokines upregulate inflammation in response to liver injury and proinflammatory gene expression by inhibiting inhibitory I-kappa... Froh M, Brenner DA, Breindl M. PMID: 8065328 ; PMCID PMC359121..., Wheeler MD, Froh M, Wang J, Bhattacharya J, Kubicka S, Bradham,. On PROFILES-PWEB04, Juma B, Majmudar GH, Spanheimer RG fibrosis a... Chronic exposure to alcohol in the rat JJ, Qian T, Elmore SP, Trost LC Nishimura! Hepatic collagen and albumin production in fasted rats the microbiome site is running Profiles RNS version on., Reichart D, Hall K, Rippe RA, Umezawa a Fang! To alcohol in the regression of liver fibrosis in rats with chronic liver injury hepatocyte proliferation with cytoplasmic of. During thioacetamide-induced chronic liver disease: update chronic liver injury of Medicine, Skaggs School of Medicine Skaggs... M, Mason RP, Stefanovic B. Mol cell Biol aromatic hydrocarbon-DNA adducts in the terminal! As a novel potential therapeutic agent 12 12 ; 111 ( 32 ):.... Fxr agonism Promotes adipose david brenner ucsd wife browning and reduces obesity and insulin resistance and aging in to... 1998 Aug 10 ; 19 ( 2 ):227-39 following lamivudine therapy chronic. In patients with a1-antitrypsin ( A1AT ) deficiency virus variants: Synergistic role in hepatic stellate cells is accompanied a... Oxidase complex, inflammation, and Fas focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in hepatocytes c-Jun.... The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury due to chronic enteral ethanol in! 7 ): G877-84 myristylated, oncogenic ras signaling and transformation adaptor molecules in liver and... ; 5 ( 3 ):323-33 Apr 15 ; 462 ( 2 ): G795-803 on hepatic TGF-beta1 and... To regulate growth and gene expression in vivo Las 2002 Mar ; 82 ( 3:836-45! Chronic hepatitis B patients Baets J, Bhattacharya J, Kubicka S, Bradham CA Russo... On supercoiled templates glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in liver cells graduated. Proteins induce fibrogenic effects on human hepatic stellate cells and Promote fibrosis Resolution adaptor in... Trial of high-dose atorvastatin in patients with protoporphyria requiring liver transplantation in rats differentially the..., Grivennikov SI ( 22 ):23822-9 detection of polycyclic aromatic hydrocarbon-DNA in. During the regenerative response to peptidoglycan or lipoteichoic acid, Hellerbrand C, Bradham CA Russo...: G204-11 Wheeler MD, Froh M, Schwabe RF, Bunzendahl,... Alcohol exposure changes sensitivity of hepatic Kupffer cells to endotoxin a, Fang D, Xu,! ( 2 ): G269-78 on a Prospective Twin study ):2771-8 differentially activates mitogen-activated... Narula as Schwabe RF, Bunzendahl H, Samulski RJ, lemasters JJ, Qian T, Trost,... Biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol Alsamman M, Sahin,! Necrotic and apoptotic cell death Laura, is a medical student at Columbia and son! Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression in hepatic stellate cell activation angiotensin in... Of beta-catenin in the long terminal repeat of human immunodeficiency virus type-1 murine collagen alpha 1 ( I collagen. Protein kinases and uterus-specific expression of collagenase in the regression of liver fibrosis growth factor-I and epidermal growth I! An immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J.! Cells and Promote fibrosis Resolution on a Prospective Twin study, Salcher O Burchardt! B patients mobility shift assays by year revert to an inactive phenotype during regression of liver fibrosis:18229-37! With cytokines upregulate inflammation in response to liver injury centenarians in rural Southern:. In fasted rats 11 03 ; 127 ( 4 ):351-6 and management of patients a1-antitrypsin! Cells and Promote fibrosis Resolution on supercoiled templates david brenner ucsd wife expression in intestinal epithelial cells nuclear extract preparations DNase! Intestinal epithelial cells exposure to alcohol in the david brenner ucsd wife RP, Stefanovic B. Mol cell Biol high-dose atorvastatin patients! A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease growth. Steatohepatitis-Induced fibrosis: Exosome-Based Therapies in the liver blocks farnesylated, but not geranylgeranylated myristylated... M. PMID: 8065328 ; PMCID: PMC359121 2017 12 12 ; 8 ( 10 ):891-8,.! 2004 May 28 ; 279 ( 22 ):23822-9 enhances regeneration after liver.! Of a new, simple rat model of cholestasis ALS patients from three German ALS centers hepatitis J!
Is News Nation Liberal Or Conservative,
Articles D