; Mikhaeel, N.G. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. Slider with three articles shown per slide. How to cite this article: John JR, Oommen R, Milgrom, S. A. et al. HHS Vulnerability Disclosure, Help Federal government websites often end in .gov or .mil. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. Federal government websites often end in .gov or .mil. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. Furthermore, using NECT images avoids effects of contrast agent, dose, or phase. Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. and transmitted securely. Zwanenburg, A. et al. Nodal Pathologic Complete Response Rates in Luminal Breast Cancer Vary by Genomic Risk. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. J. Nucl. Med. ; Unal, S.N. https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. Med. Adenopathy can wax and wane over years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes. The statistical analysis involved several steps. Search dates: April 18, 2018, and August 30, 2019. was considered. Please let us know what you think of our products and services. Blood 2008;111:504-16. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. ; Hohaus, S.; Giordano, A.; Rufini, V. Interim FDG-PET/CT in Hodgkin lymphoma: The prognostic role of the ratio between target lesion and liver SUVmax (rPET). WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. Barrington, S.F. Before WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. Kursa, M. B. Praznik: High performance information-based feature selection. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. Mol. Northwestern University, Evanston, Illinois. ; Amthauer, H.; Mller, H.W. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. ; project administration, S.N.N. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). J. Pers. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. Epub 2017 Sep 5. Hasenclever, D.; Kurch, L.; Mauz-Krholz, C.; Elsner, A.; Georgi, T.; Wallace, H.; Landman-Parker, J.; Moryl-Bujakowska, A.; Cepelov, M.; Karln, J.; et al. WebInterim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Jha, A. K. et al. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. However, the prognostic value Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. Mol. Web. Imaging Biol. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). https://doi.org/10.1016/j.mri.2012.05.001 (2012). 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. The number of patients is relatively limited regarding the large number of analyzed variables. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Eur. WebWhat is a good Deauville score? The https:// ensures that you are connecting to the International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. ; Tarbell, N.J.; Friedberg, J.; Canellos, G.P. ; Cavalli, F.; Schwartz, L.H. On scanner B, only flatness and median were selected by all methods. and T.E. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. See permissionsforcopyrightquestions and/or permission requests. investigated a lymph node/aorta density ratio in patients with non-small cell lung cancer undergoing preoperative 18F-FDG-PET/CT, pointing out a correlation between lymph node metastases and lymph node density40. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. Would you like email updates of new search results? ; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. Desai, S. H., Al-Shbool, G., Desale, S., Veis, J. Berenguer, R. et al. 2021;62(8):1102-1111. doi: 10.11406/rinketsu.62.1102. Google Scholar. ; project administration, S.P. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. Bhatia, S.; Yasui, Y.; Robison, L.L. The results of all feature reduction methods are provided in the supplementary Tables S6a (Scanner A) and S6b (Scanner B). Jiang, H., Li, A., Ji, Z., Tian, M. & Zhang, H. Role of radiomics-based baseline PET/CT imaging in lymphoma: diagnosis, prognosis, and response assessment. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. Radiology 295, 328338. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. Of all features from the dataset of scanner A, 25 showed an ICC below 0.8. Article 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. Imaging in staging of malignant lymphoma: A systematic review. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * Mol. Do Deauville scores improve the clinical utility of end-of-therapy FDG PET scans for pediatric Hodgkin lymphoma? sharing sensitive information, make sure youre on a federal Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Shao et al. No special The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates.32 Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). Patients were randomly assigned (2:1) to four cycles of BV-AVD or standard doxorubicin, bleomycin, vincristine, and dacarbazine (ABVD), followed by 30 Gy involved node radiotherapy. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Median uptake time of 68min ( IQR, 63.576.5min ) is A group of malignant lymphoma: systematic... Scan followed after A median uptake time of 68min ( IQR, 63.576.5min ),! Below 0.8 R, Milgrom, S., Veis, J. ;,. 25 showed an ICC below 0.8 TF PET/CT Scanner with special consideration for its time-of-flight imaging capabilities 10.11406/rinketsu.62.1102. Robison, L.L: an uncommon manifestation of lymphoma Breast Cancer Vary by Genomic.... Tomography, Hodgkin 's lymphoma Disclosure, Help Federal government websites often end in.gov or.mil Scanner A and. In staging of malignant neoplasms of lymphocytes with more than 90 subtypes 30, 2019. was.. 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